The Gray Zone in Thyroid Nodules: Atypia of Undetermined Significance/Follicular Lesion with Unknown Significance

Major purpose of the management of thyroid nodules is to distinguish between malignant nodules and the benign ones. Nodules with the cytology result Atypia of Undetermined Signifi cance or Follicular Lesion of Undetermined Signifi cance are still a diagnostic challenge. Initial presentation of the Bethesda System was based on 7% diagnosing rate and around 5-15% malignancy rate for these nodules; however, clinical practice presents with higher rates for both variables. Recent studies showed that when these nodules are grouped by cytological features; compared with the architectural atypia group, the cytological atypia group has a signifi cantly higher risk of malignancy. Cytological sub-classifi cation, ultrasonographic evaluation and genetic tests in selected cases should be used in the management of these nodules. Mini Review The Gray Zone in Thyroid Nodules: Atypia of Undetermined Signifi cance/ Follicular Lesion with Unknown Signifi cance Selami Ilgaz Kayılıoğlu*, Ufuk Utku Göktuğ and Tolga Dinç Ankara Numune Eğitim ve Araştırma Hastanesi, Hacettepe Mah Talatpaşa Bul No. 4, Altindag, Turkey Dates: Received: 01 June, 2017; Accepted: 12 June, 2017; Published: 13 June, 2017 *Corresponding author: Selami Ilgaz Kayılıoğlu, Department of General Surgery, Ankara Numune Research and Training Hospital, Turkey, Tel: 00-90 533 203 6595; Fax: 00-90 312 311 4340; E-mail: